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Combine water and beef base in a 6-quart slow cooker and stir well.
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Add prime rib, potatoes, frozen vegetables, red wine, onion, ketchup, celery, carrots, garlic, parsley, thyme, salt, and pepper. Cook on Low until vegetables are tender, 6 to 8 hours.
Cook’s Note:
I use LeGout(R) beef base from a restaurant supply store rather than beef broth or beef boullion. I find it adds better flavor. Adjust amount to your taste.